Richard Hendriks, Ph.D.

Richard Hendriks, Ph.D.

“We face shifting paradigms for success as we position ourselves as global industry experts. Nowhere is this more apparent than in the pharmaceutical industry.”

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Analyst Richard Hendriks, Ph.D., partners with pharmaceutical companies to discover the most effective ways of meeting their business goals. This encompasses a range of solutions from innovations in biotechnology to analytical assessments of recent trends in disease treatments. Qualitative analyses of citation and patent literature is the foundation of such endeavors, and Dr. Hendriks has specialized in this area for almost 10 years with Nerac. During that time, he has gained significant industry and government insight. He has a Ph.D. in neuroscience from University of Melbourne, Australia, and a background in neuronal electrophysiology.

During his research career, Dr. Hendriks received several grants and fellowships from the National Institutes of Health and the National Science Foundation. He was a principal investigator for early collaborative research with Sandoz that focused on neuronal receptor pharmacology for a compound that was eventually commercialized as Tropisetron. His subsequent research focused on the central nervous system and included an investigation into the role of potassium channels in embryonic neuronal migration as part of an investigation into potential cures for deafness. Dr. Hendriks has authored dozens of published articles and abstracts on physiology and electrophysiology.

Besides neuroscience and electrophysiology, Dr. Hendriks’ areas of expertise include neurophysiology, pharmacology, drug development, electrophysiology, bioengineering and neurotransmitters.

Credentials

  • Ph.D., Neuroscience, University of Melbourne, Australia
  • B.Sc. Hons, Medical Physiology, Flinders University of South Australia
  • B.Sc., Biophysics, Flinders University of South Australia (FUSA) 

Grants and Fellowships

  • NIH, National Institute on Deafness and Communicative Disorders (NIDCD) T32 DC00025-12: from 8-1-94 to 8-1-96. “Communicative Disorders: Cellular and Neural Biology.” Role: Principal Investigator
  • NIH, National Institute on Deafness and Communicative Disorders (NIDCD) F32 DC00267-01: from 12-1-96 to 12-1-97. “Role of potassium channels in neuronal migration”. Role: Principal Investigator
  • NIH, National Institutes of Health, RO1 from 1-1-99 to 12-31-01. “Prenatal Protein Malnutrition and Hippocampal Plasticity.” Role: Research Associate
  • NIH, National Institutes of Health, R21, Technology Grant 1-1-2000 to 12-31-2001"Neurophysiology of the Developing Hippocampus” Role: Research Associate
  • NSF, National Science Foundation, RU1, . 6-15-99 –6-15-2002. “ Noradrenergic changes associated with hippocampal LTP in the freely moving male and female rat.” Role: Research Associate
  • NIH, National Institutes of Health, R15, AREA GRANT. 1-1-2000 to 12-31-2001"Neurophysiology of the Developing Hippocampus” Role: Research Associate

Publications

  • Hendriks, R, “Spinal Cord Stimulation and Parkinson's Disease”, Nerac Insights, http://www.nerac.com/nerac_insights.php?category=articles&id=180, April 2009
  • Hendriks, R, “Neuroscience and Carbon Nanotubes”, Nerac Insights, http://www.nerac.com/nerac_insights.php?category=articles&id=179, April 2009
  • Hendriks, R, “Risk Assessment: Nerac develops methodology to assess drug and technology success potential”, Nerac Insights, http://www.nerac.com/nerac_insights.php?category=articles&id=129, October 2008
  • Hendriks, R, “Patent News: Retinal implants open the shutters on blindness”, SPIE, http://spie.org/x34979.xml?ArticleID=x34979, May 1, 2009
  • Hendriks, R, “Off the Label: Contrary to Reports, FDA Guidelines for Off-Label Promotion Tighten Loopholes”, Nerac Insights, http://www.nerac.com/nerac_insights.php?category=articles&id=14, March 2008
  • Hendriks, R, “Pharma's Strategic Outlook: Conference Buzz in New York Centers on Alliances and M&A Activity”, Nerac Insight, http://www.nerac.com/nerac_insights.php?category=articles&id=16, March 2008
  • Hendriks, R, “Bionic Eyes: Retinal Implants, Still in their Infancy, Provide a New Vision of the Future”, Nerac Insights, http://www.nerac.com/nerac_insights.php?category=articles&id=35, March 2008
  • Bronzino, JB, Kehoe, P, Hendriks, R, Vita, L, Golas, B, Vivona, C and Morgane, PJ, “Hippocampal Neurochemical and Electrophysiological Measures from Freely Moving Rats”, Exp. Neurol. 155: 150-155, 1999
  • Morest, DK, Hendriks, R, Kaczmarek, LK, “Role in neuronal cell migration for high-threshold potassium currents in the chicken hindbrain”, Journal of Neuroscience Research 58 (6) 805-814, 1999
  • Morest, DK, Hendriks, R, Kaczmarek, LK, “Shaw-like potassium currents in the auditory rhombencephalon throughout embryogenesis”, Journal of Neuroscience Research 58 (6) 791-804, 1999
  • Kunze, WAA, Bornstein, JC, Furness, JB, Hendriks, R, and Stephenson, D.S.H.. “Charybdotoxin and iberiotoxin but not apamin abolish the slow afterhyperpolarization in myenteric plexus neurons”, Pfluger’s Arch. 428: 300-306, 1994
  • Hendriks, R, Kreulen, DL, “Evidence for a sodium-dependent outward current in cultured stellate ganglion neurons of the guinea-pig”, Biophysical Journal 66 (2) - 2 PP. A254, 1994
  • Hendriks, R, Coggan, JS, Knoper, SR, Purnyn, SL, Xian, H, Anthony, TL and Kreulen, DL, “Electrophysiology of cultured sympathetic neurons”, In: Innervation of the Gut: Pathophysiological  Implications, Eds. Tache, Y, Wingate, DL and Burks, TF CRC press. Boca Raton, USA. pp 137-149, 1992
  • Bornstein, JC Hendriks, R, Furness, JB, and Trussell, DC, “Ramifications of the axons of neurons with sustained post-spike hyperpolarizations and type II morphology in the myenteric plexus of the guinea-pig small intestine”, J. Comp. Neurol. 314 (3): 437-451, 1991
  • Hendriks, R, Bornstein, JC and Furness, JB, “An electrophysiological study of the projections of the putative sensory neurons within the guinea-pig ileum”, Neurosci. Lett. 110: 286-290, 1990
  • Hendriks, R, Bornstein, JC and Furness, JB, “Evidence for two types of 5-hydroxytryptamine receptor on secretomotor neurons of the guinea-pig ileum,” Naunyn-Schmied. Arch. Pharmacol. 339: 409-414, 1989
  • Pompolo, S, Furness, JB, Bornstein, JC Hendriks, R and Trussell, DC, “Dogiel type II neurons in the guinea-pig small intestine: ultrastructure in relation to other characteristics,” In Nerves in the Gastrointestinal Tract, Eds: Singer, MV and Goebell, H, Martin Lister, Carnforth, U.K., pp 57-67, 1989      

Abstracts

  • Roy, K,  Kehoe, P,  Hendriks, R,  Fortin, DF,  Bronzino, JD, ”Increased norepinephrine levels are associated with the induction of LTP in  the dentate gyrus of the freely moving rat”, 25 (1-2); 881, 1999
  • Hendriks, R,  Morest, DK, and Kaczmarek, LK, “Voltage - dependent potassium channels may influence neuronal cell migration”, Am. Neurosci. Soc. 27th Meeting Abstr., New Orleans LA, USA, 1997
  • Hendriks, R, Kaczmarek, LK, and Morest, DK, “The influence of growth factors on the developmental expression of high threshold outward currents in cultured acoustico-vestibular neurons of the chicken”, Association for Research in Otolaryngology (ARO): 20th Meeting, St. Petersburg Beach, Florida, 1997
  • Hendriks, R, Morest, DK, and Kaczmarek, LK, “Development of Kv3.1 - mediated potassium currents in cultured acoustico - vestibular neurons of the chicken”, Association for Research in Otolaryngology (ARO): 19th Meeting, St. Petersburg Beach, Florida, 1996
  • Hendriks, R, Hossain, WAW, Morest, DK, Kaczmarek, LK, Davidson, RM, and Ostapoff, E-M, “Development of  Kv3.1-like currents in acoustico-vestibular neurons of the chicken embryo brain in vitro”, Am. Neurosci. Soc. 25th Meeting Abstr. 25: 718.2, San Diego CA, USA, 1995
  • Zheng, ZL, Satterfield, B, Dey, RD, Anthony, TL, Hendriks, R, and Kreulen, DL, “Nitric oxide of primary sensory origin is a neuromodulator in sympathetic ganglia and blood vessels”, Am. Neurosci. Soc. 25th Meeting Abstr. 25: 453.1, San Diego CA, USA, 1995
  • Morris, MG, Hendriks, R and Kreulen, DL, “Electrophysiological characterization of stellate ganglion (SG) neurons supplying the lung in the guinea-pig”, ALA/ATS International Conference 1994, Boston MA, 1994
  • Hendriks, R and Kreulen, DL, “Evidence for a sodium dependent outward current in cultured stellate ganglion neurons of the guinea-pig”, 38th Biophysical Society Meeting, New Orleans, Abstr. 38: A254, 1994
  • Hendriks, R, Karim, G-EMM and Kreulen, DL, “Electrophysiological characteristics of stellate ganglion neurons of the guinea-pig”, Am. Neurosci. Soc. 23rd Meeting (Washington DC, USA) Abstr. 23: 626.13, 1993
  • Hendriks, R, Knoper, SR and Kreulen, DL, “Anatomical organization of intrinsic neurons of the rabbit trachea”, Am. Neurosci. Soc. (Anaheim, USA) Abstr. 22: 475.20, 1992
  • Hendriks, R, Coggan, JS, Knoper, SR, Purnyn, SL, Xian, H, Anthony, TL and Kreulen, DL, “Electrophysiology of cultured sympathetic neurons”, International Symposia on Brain - Gut Interactions at Queens’ College, Cambridge (England), July 7 - 10, 1992
  • Anthony, TL, Hendriks, R, and Kreulen, DL, “Effect of Nw-nitro-L-arginine methyl ester (L-NAME) on stimulation evoked slow excitatory synaptic potentials in guinea-pig inferior mesenteric ganglion neurons”, Am. Motility. Soc. Meeting, Lake Tahoe, USA, 1992
  • Bornstein, JC, Furness, JB and Hendriks, R, “Projections and terminals of the enteric sensory neurons that mediate mucosa to muscle reflexes”, Proc. XIIIth Int. Symposium on G.I. Motility, Reno, NV. USA, 1991
  • Hendriks, R, Kunze, WAA, Bornstein, JC and Furness, JB, “Charybdotoxin selectively blocks the prolonged post-spike afterhyperpolarizations in AH neurons of the guinea-pig small intestine”, Proc. Aust. Physiol. Pharmacol. Soc., Melbourne, Aust., 22, 110P, 1991
  • Hendriks, R and Furness, JB, “Characteristics of the neural code for individual myenteric AH neurons of the guinea-pig small intestine”, Proc. Aust. Physiol. Pharmacol. Soc., Melbourne, Aust., 22, 109P, 1991
  • Furness, JB, Bornstein, JC, Smith, TK and Hendriks, R, “Physiological and morphological characterization of tertiary plexus neurons of the guinea-pig small intestine”, Proc. Aust. Physiol. Pharmacol. Soc., Sydney, Aust., 21, 142P, 1990
  • Hendriks, R, Bornstein, JC and Furness, JB, “Terminal arborizations of presumed sensory neurons of the guinea-pig ileum revealed after intracellular injection of biocytin”, Proc. Aust. Neurosci. Soc., Brisbane, Aust.. 1, 85, 1990
  • Furness, JB, Bornstein, JC, Hendriks, R and Trussell, D, “Terminal ramifications and conduction properties of the axons of myenteric AH neurons in the guinea-pig small intestine”, AGA/AASLD Meeting: San Antonio, Texas, Gastroenterology 98: A352, 1990
  • Hendriks, R, Bornstein, JC and Furness, JB, “Two types of 5-HT receptor on submucosal secretomotor neurons revealed by the use of a 5-HT3 receptor antagonist (ICS 205-930)”, Australian Neuroscience Society (ANS) Meeting. Canberra, Australia. Neurosci. Lett. 30: S75. 1988

Presentations

  • Hendriks, R, “Retinal implants open the shutters on blindness--recent innovations”, ASME Emerging Technologies 4th Annual Frontiers in BioMedical Devices Conference 2009, Hyatt Regency Irvine, Irvine, California, June 9, 2009
  • Hendriks, R and Bridgers, A, “Post-Small Molecule Pharmaceuticals:  Patent Analysis and CI  for Combination Therapeutics”, Pharma CI Conference, Woodbridge Hotel, Iselin, New Jersey, September 15-16, 2008

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ARTICLES

Off the Label: Contrary to Reports, FDA Guidelines for Off-Label Promotion Tighten Loopholes

Recent media reports about the FDA’s plans to set guidelines for the kinds of literature drug makers can use to support the off-label use of FDA-approved drugs largely missed the mark.

Pharma's Strategic Outlook: Conference Buzz in New York Centers on Alliances and M&A Activity

What most of the top managers had on their minds at Windhover Information’s Pharmaceutical Strategic Outlook meeting in New York City in mid-March was the unprecedented level of alliances and M&A activity that has taken place over the past few years as the industry copes with momentous changes.

Bionic Eyes | Retinal Implants, Still in their Infancy, Provide a New Vision of the Future

Risk Assessment

Nerac Develops Methodology to Assess Drug and Technology Success Potential

Neuroscience and Carbon Nanotubes

Over the past decade or so, there has been increasing interest in the use of carbon nanotubes to repair damaged neurons, and for nerve-tissue engineering in general, partly due to the excellent electrical conduction properties, chemical and thermal stability, and discernible biocompatibility properties of this material.

Spinal Cord Stimulation and Parkinson's Disease

With so much zeal and promise associated with embryonic stem cells (and far too little on adult stem cells, in my opinion), I find it rewarding to see non-stem cell research coming up with significant advances for treating neurodegenerative diseases.

GENERAL

Nerac Analysts present at PharmaCI Conference, September 2008

Pharma CI Conference
September 15-16, 2008
Woodbridge Hotel, Iselin, New Jersey  

Join Nerac Analysts Richard Hendriks and Avis Bridgers, presenting “Post-Small Molecule Pharmaceuticals:  Patent Analysis and CI  for Combination Therapeutics”.

Nerac Analyst Richard Hendriks, Ph.D., presents at ASME 2009

Nerac Analyst Richard Hendriks, Ph.D., will present “Retinal implants open the shutters on blindness - recent innovations” on Tuesday June 9, from 1:00-2:20pm. Read more.

Retinal Implants Open the Shutters on Blindness | Published in SPIE Newsroom April 09

This patent review written by Nerac Analyst Richrad Hendriks explores new developments in retinal implants that may speed their acceptance for treating blindness. Read more.

CONTACT

Richard Hendriks, Ph.D. Nerac
  • One Technology Drive
  • Tolland, CT 06084