By John Leavitt, Ph.D., Nerac Analyst,
Originally Published: February 17th, 2015
The emergence of the role of “Epithelial to Mesenchymal Transition” (EMT) is the most important development in cancer research since the discovery of oncogenes in the 1980’s. Tumor cell EMT provides a mechanism for acquiring chemo-resistance of tumors and metastasis that has only recently been appreciated by companies developing anti-cancer and anti-fibrosis diagnostics and drugs.
- 52By John Leavitt, Ph.D. Nerac Analyst Originally Published: August 12, 2014 In 1987, my colleagues at Stanford and I published a paper that clearly demonstrated that expression of a charge-altered mutant human beta-actin (glycine to aspartic acid substitution at amino acid 245; G245D) caused non-tumorigenic, immortalized human fibroblasts to form aggressive tumors in nude mice (Leavitt…
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